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KMID : 0361520080190040226
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Korean Journal of Psychopharmacology
2008 Volume.19 No. 4 p.226 ~ p.232
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Relationship between Obsessive-Compulsive Disorder and Monoamine Oxidase-A Genetic Polymorphisms in a Korean Population
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Koh Min-Jung
Kim Se-Joo
Kim Chan-Hyung
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Abstract
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Objective: There is increasing evidence that obsessive-compulsive disorder (OCD) is a multidimensional and heterogeneous disorder mediated by a range of different factors, including genetic variation. Our aim was to investigate the possible association of OCD with monoamine oxidase-A (MAO-A) gene polymorph isms in a Korean population.
Methods: Patients with OCD (N=121) and normal individuals (N=276) participated. Genomic DNA was extracted from the peripheral blood of all subjects, and genotypes were determined. Males and females were treated as separate groups because the MAO-A gene is located on the X chromosome. MAO-A genotypes and allele frequencies were compared with the Yale-Brown Obsessive-Compulsive Scale (YBOCS) factor scores of both groups.
Results: Male OCD patients exhibited a higher frequency of allele 3.00 and a lower frequency of allele 4.00 than did normal male patients. Additionally, male patients with allele 4.00 scored higher for YBOCS factor 1 (obsession: hoarding ; compulsion : counting, repeating, hoarding, ordering) than did those with allele 3.00.
Conclusions: The MAO-A gene may be associated with the development of OCD in males. Further study is necessary to evaluate the relationship between OCD and MAO-A genetic polymorphisms.
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KEYWORD
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Monoamine Oxidase-A, Polymorphism, Obsessive-Compulsive Disorder
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